What is Antidote OSRS?

Old School RuneScape (OSRS) is a massively popular multiplayer online role-playing game that has captivated millions of players worldwide. Among the numerous items and potions available in the game, the Antidote stands out as a crucial element for many adventurers. Whether you’re a seasoned player or a newcomer, understanding what Antidote OSRS is, its uses, and how to obtain it can significantly enhance your gaming experience. This comprehensive guide delves into the details of Antidote OSRS, its benefits, and strategies for effective usage.

What is Antidote OSRS?

In Old School RuneScape, the term “Antidote” generally refers to specific types of potions that players use to cure or prevent poison. Poison is a common threat in OSRS, encountered in various combat situations, especially when facing venomous creatures or engaging in player-versus-player (PvP) combat. Antidote potions come in different forms, each with unique properties and durations of protection.

Types of Antidote Potions

  1. Antidote+ (1)
  2. Antidote+ (2)
  3. Antidote+ (3)
  4. Antidote+ (4)
  5. Antidote++ (1)
  6. Antidote++ (2)
  7. Antidote++ (3)
  8. Antidote++ (4)

Understanding Antidote+ and Antidote++

Antidote+ and Antidote++ are the two main variants of antidote potions in OSRS, each offering varying levels of protection against poison.


Antidote+ potions provide a 12-minute immunity to poison and heal any current poison effects on the player. They come in doses of 1, 2, 3, and 4, with the number indicating the remaining uses of the potion.


Antidote++ potions are a more potent version, offering a 15-minute immunity to poison and curing any existing poison. Like Antidote+, these also come in doses of 1, 2, 3, and 4.

How to Obtain Antidote OSRS

Acquiring Antidote potions in OSRS involves several methods, including crafting through the Herblore skill, purchasing from other players, or obtaining them as drops from specific monsters.

Crafting Antidote Potions

To craft Antidote+ and Antidote++ potions, players need to have a certain level of the Herblore skill and the required ingredients.

For Antidote+:

  • Herblore Level Required: 68
  • Ingredients: Toadflax and Yew roots

For Antidote++:

  • Herblore Level Required: 79
  • Ingredients: Irit leaf and Magic roots

Crafting Process:

  1. Gather the required herbs (Toadflax for Antidote+ and Irit leaf for Antidote++).
  2. Clean the herbs.
  3. Combine the cleaned herb with a vial of water.
  4. Add the secondary ingredient (Yew roots for Antidote+ and Magic roots for Antidote++).

Purchasing Antidote Potions

Players can also purchase Antidote potions from other players through the Grand Exchange or in player-to-player trades. Prices may vary depending on market demand and supply, so it’s a good idea to check the current prices before making a purchase.

Monster Drops

Certain monsters in OSRS have a chance to drop Antidote potions. Some notable monsters include:

  • Venenatis
  • Callisto
  • Vet’ion

These bosses are part of the Wilderness area, so players should be cautious and prepared for potential PvP encounters when farming these monsters for antidote drops.

Uses and Benefits of Antidote OSRS

Antidote potions are invaluable for several reasons, particularly for their ability to counteract poison and provide temporary immunity. Here’s a detailed look at their primary uses and benefits:

Combat Situations

In many combat scenarios, especially in areas like the Wilderness, Slayer tasks, or boss fights, players encounter venomous creatures that can inflict poison. Using an Antidote potion not only cures the poison but also provides a crucial period of immunity, allowing players to focus on the fight without worrying about the recurring poison damage.

Player-Versus-Player (PvP) Combat

In PvP combat, particularly in the Wilderness, poison can be a strategic tool used by players to weaken their opponents. Having Antidote potions handy ensures that you can quickly cure any poison inflicted by enemy players, giving you a significant advantage and increasing your chances of survival.

Slayer Tasks

Many Slayer tasks involve fighting monsters that can poison you. Bringing Antidote potions during these tasks can make the process smoother and more efficient, as you won’t need to constantly retreat or consume food to counteract the poison damage.

Efficiency in Training

For players engaged in long training sessions, particularly in areas with venomous creatures, Antidote potions help maintain efficiency. By preventing poison damage and the associated downtime, players can maximize their experience gains and minimize the need for frequent breaks.

Strategies for Using Antidote OSRS

Effectively using Antidote potions in OSRS involves strategic planning and understanding when and how to use them. Here are some tips to get the most out of your antidote potions:

Preemptive Use

In areas known for poison threats, such as the Wilderness or during specific boss fights, it’s wise to use an Antidote potion preemptively. This not only cures any existing poison but also grants you a significant period of immunity, allowing you to focus on your objectives without worrying about being poisoned.

Inventory Management

Keep a balanced inventory with enough antidote potions to last through your intended activity. For example, if you’re planning an extended Wilderness trip or a long Slayer task, bring multiple doses of Antidote+ or Antidote++ to ensure continuous protection.

Combination with Other Potions

In combat situations, combine Antidote potions with other beneficial potions like Super Restore, Saradomin Brew, or Combat potions. This strategy enhances your overall combat effectiveness while ensuring you remain protected from poison.

Quick Access

Assign Antidote potions to a quick access slot or keep them in an easily reachable position in your inventory. In high-pressure situations, quick access to your antidote can be the difference between life and death.

Comparing Antidote OSRS to Other Anti-Poison Potions

OSRS offers several types of anti-poison potions, each with unique properties. Comparing these options can help you choose the best potion for your needs.


  • Duration of Immunity: None (cures poison only)
  • Herblore Level Required: 5
  • Ingredients: Marrentill and Ground unicorn horn


  • Duration of Immunity: 6 minutes
  • Herblore Level Required: 48
  • Ingredients: Irit leaf and Ground unicorn horn

Sanfew Serum

  • Duration of Immunity: 6 minutes
  • Herblore Level Required: 65
  • Ingredients: Super Restore potion, Unicorn horn dust, Snake weed, Nail beast nails

Antidote+ and Antidote++

  • Duration of Immunity: 12 minutes (Antidote+), 15 minutes (Antidote++)
  • Herblore Level Required: 68 (Antidote+), 79 (Antidote++)
  • Ingredients: Toadflax/Yew roots (Antidote+), Irit leaf/Magic roots (Antidote++)


Choosing the right anti-poison potion depends on your specific needs and the duration of protection required. For longer-lasting immunity, Antidote+ and Antidote++ are the best options, particularly for extended adventures or high-risk areas.

Understanding and utilizing Antidote potions in OSRS is essential for any player aiming to enhance their gameplay experience. Whether you’re battling venomous creatures, engaging in PvP combat, or completing Slayer tasks, having Antidote+ or Antidote++ potions in your inventory can make a significant difference. By knowing how to obtain, use, and strategize with these potions, you can ensure maximum efficiency and protection against poison in Old School RuneScape.

Remember, responsible use of Antidote potions not only improves your gaming performance but also enhances your overall enjoyment of the game. So, stock up, stay prepared, and venture into the world of OSRS with confidence and safety.

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