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Midazolam price has become a key concern in healthcare systems, especially for hospitals, surgical centers, and emergency care providers. As of 2025, the cost of Midazolam continues to fluctuate due to manufacturing sources, supply chain shifts, brand vs generic availability, and regulatory frameworks. Let’s explore the updated pricing details of Midazolam prescription in its various forms—vial, injection, and syrup.
Midazolam Injection Price (per vial)
The injectable form of Midazolam is widely used for sedation and seizure management. Prices vary based on dosage strength and manufacturer:
| Strength | Quantity | Brand | Average Price (USD) |
|---|---|---|---|
| 1 mg/mL | 2 mL vial | Generic | $3 – $6 |
| 5 mg/mL | 2 mL vial | Hospira | $7 – $12 |
| 5 mg/mL | 10 mL vial | Pfizer | $18 – $30 |
| 5 mg/mL | 10 mL vial | Generic | $12 – $25 |
Key Insight: Generic Midazolam typically costs 20%–40% less than branded versions, with bulk hospital purchases enjoying further discounts through GPO contracts.
Midazolam Oral Syrup Price (Primarily Pediatric Use)
Oral syrup formulations are less common but important in pediatric and pre-op sedation:
| Form | Strength | Average Price (USD) |
|---|---|---|
| Syrup | 2 mg/mL (120 mL bottle) | $70 – $150 |
| Compounded | Variable | $40 – $80 |
Note: Prices are higher due to compounding needs and limited FDA-approved oral formulations.
Midazolam Nasal Spray Price
Approved for seizure clusters, the nasal spray format has a more premium cost due to convenience and regulatory status.
| Brand | Strength | Average Price (USD) |
|---|---|---|
| Nayzilam | 5 mg (per spray unit) | $620 – $700 |
| Generic | 5 mg | $500 – $650 |
Insurance Status: Often partially covered under emergency seizure management indications. Still, copays can be as high as $50–$200 per spray for uninsured patients.
Midazolam Cost Comparison by Region
Global price variation depends on procurement systems:
| Country | Unit Price (Generic, 5 mg/mL) |
|---|---|
| USA | $2.50 – $6.00 per mL |
| UK (NHS) | £1.50 – £4.00 per mL |
| India | ₹15 – ₹40 per mL (approx. $0.20 – $0.50) |
| Kenya | KSh 100 – 300 per mL (approx. $0.80 – $2.50) |
| Australia | AUD 2.00 – AUD 5.00 per mL |
Government hospitals in developing countries may receive subsidized pricing under WHO procurement guidelines.
Factors Influencing Midazolam Price
- Generic Availability: Increases market competition, lowering prices.
- Raw Material Supply: Benzodiazepine base shortages spike the cost.
- Regulations: Controlled substance status limits suppliers.
- Batch Production: Short shelf life increases manufacturing frequency and overheads.
- Pandemic Backlog: Still causing occasional shortages and price spikes in 2025.
Bulk Hospital Pricing & Discounts
Group purchasing organizations (GPOs), such as Vizient or Premier, can reduce the Midazolam price by up to 50% for high-volume hospitals. Direct wholesaler contracts (e.g., McKesson, Cardinal Health) also offer tiered pricing, with discounts improving with larger order volumes.
| Purchase Volume | Expected Discount |
|---|---|
| 1–99 vials/month | No discount |
| 100–499 vials/month | 10% – 15% |
| 500+ vials/month | 20% – 30% |
Retail vs. Institutional Pricing
While institutional pricing is negotiated, retail pharmacies typically charge more:
- Retail 2 mL vial (5 mg/mL): $8 – $15
- Hospital 2 mL vial (5 mg/mL): $4 – $7
- Online pharmacy (licensed): $6 – $12 per unit (shipping not included)
Is Midazolam Covered by Insurance?
Yes, but coverage varies:
- Commercial Plans: Usually cover injectable and nasal spray forms with copays between $5 – $75.
- Medicare/Medicaid: Typically covers most uses, especially under Part B for hospital-administered sedation.
- Out-of-pocket (uninsured): Expect higher retail markups unless sourcing from generic-only pharmacies.
How to Save on Midazolam
- Use Generic: Ask prescribers to write “Generic OK” or “Substitution allowed.”
- Midazolam Online Coupons: GoodRx(Midazolam) or SingleCare may offer discounts up to 50%.
- Nonprofit Programs: Some NGOs and community clinics offer Midazolam at cost or free for epileptic patients.
- Hospital Financial Assistance: Emergency sedatives like Midazolam are often discounted under hardship programs.
Midazolam Price in 2025
The Midazolam price in 2025 remains relatively stable for injectables but continues to be high for specialized forms like nasal sprays. Hospitals benefit from negotiated discounts, while retail buyers may face moderate to high costs. By leveraging generics, wholesale programs, or insurance options, healthcare providers and patients can significantly reduce their out-of-pocket expenses for this essential sedative.
If you’re a medical procurement officer, healthcare provider, or patient looking to reduce Midazolam costs, always compare prices from multiple sources and explore bulk or generic options.
Want real-time Midazolam price updates or bulk supply quotes?
Contact your hospital GPO or licensed distributor to get the most accurate regional pricing. In case of an overdose, find the best antidote for a Midazolam overdose.
