Are you looking for an alternative to Entresto? Discover the best prescription and also natural substitutes for managing heart failure, including cost-effective and insurance-friendly options.
Entresto (sacubitril/valsartan) has been a breakthrough in the treatment of heart failure, but not everyone can take it. Whether due to cost, insurance restrictions, side effects, or personal preference, many patients search for an alternative to Entresto. This article explores both prescription-based and natural alternatives, helping you make an informed decision about your heart health.
Why Look for an Alternative to Entresto?
Before diving into alternatives, let’s explore why some patients consider switching from Entresto:
- Cost Concerns – Entresto is expensive, especially if you have no insurance or with high copays.
- Side Effects – Common issues include dizziness, hyperkalemia (high potassium levels), and low blood pressure.
- Insurance Coverage – Some plans do not fully cover Entresto, making it financially unviable.
- Medical Conditions – Not all patients can take Entresto due to kidney disease, low blood pressure, or angioedema history.
If any of these reasons apply to you, let’s explore your best alternatives.
Prescription Alternatives to Entresto
If you need a prescription-based alternative, consider the following medications:
1. ACE Inhibitors (Angiotensin-Converting Enzyme Inhibitors)
ACE inhibitors have been used for decades to treat heart failure and high blood pressure. They work by relaxing blood vessels and improving blood flow.
- Lisinopril (Prinivil, Zestril)
- Enalapril (Vasotec)
- Ramipril (Altace)
2. ARBs (Angiotensin II Receptor Blockers)
If you cannot tolerate ACE inhibitors due to cough or angioedema, ARBs might be a suitable alternative.
- Losartan (Cozaar)
- Valsartan (Diovan) – One of the components of Entresto, but without sacubitril.
- Candesartan (Atacand)
3. Beta-Blockers
These medications slow the heart rate and reduce its workload, helping heart failure patients manage symptoms.
- Carvedilol (Coreg)
- Metoprolol Succinate (Toprol-XL)
- Bisoprolol (Zebeta)
4. Mineralocorticoid Receptor Antagonists (MRAs)
These medications help manage fluid retention and improve heart function.
- Spironolactone (Aldactone)
- Eplerenone (Inspra)
5. SGLT2 Inhibitors (New FDA-Approved Option for Heart Failure)
Recent studies have shown that diabetes medications called SGLT2 inhibitors also improve heart failure outcomes.
- Empagliflozin (Jardiance)
- Dapagliflozin (Farxiga)
Natural & Lifestyle Alternatives to Entresto
If you’re looking for non-prescription alternatives, lifestyle modifications, and supplements can play a role in heart failure management.
1. Dietary Changes
- Low-Sodium Diet – Reducing salt intake lowers blood pressure and reduces fluid retention.
- High-Potassium Foods – Bananas, avocados, and sweet potatoes can help maintain electrolyte balance.
2. Supplements
- Coenzyme Q10 (CoQ10) – Supports heart function and may help with energy production.
- Omega-3 Fatty Acids – Found in fish oil, they help lower inflammation and reduce heart disease risk.
- Magnesium – Supports heart rhythm and blood pressure.
3. Exercise and Weight Management
- Moderate exercise, such as walking or swimming, can strengthen the heart.
- Weight management reduces the strain on your heart and lowers blood pressure.
4. Stress Management & Sleep
- Meditation, yoga, and deep breathing can reduce heart strain.
- A good night’s sleep is essential for cardiovascular health.
Which Alternative is Right for You?
The best alternative depends on your specific condition and doctor’s recommendation. Here’s a quick comparison:
| Alternative | Best For | Key Benefit |
|---|---|---|
| Lisinopril (ACE Inhibitor) | Patients with hypertension & heart failure | Well-studied, effective |
| Losartan (ARB) | Patients who cannot tolerate ACE inhibitors | Fewer side effects |
| Carvedilol (Beta-Blocker) | Patients needing lower heart rate | Improves survival in heart failure |
| Empagliflozin (SGLT2 Inhibitor) | Patients with diabetes & heart failure | New FDA-approved option |
| CoQ10 & Omega-3s | Patients looking for natural options | Supports heart health |
Talk to Your Doctor
Switching from Entresto to an alternative is a medical decision that should be discussed with your doctor. Before making the switch, consider factors like cost, insurance coverage, side effects, and effectiveness.
If Entresto isn’t working for you, plenty of other prescription medications and lifestyle changes can support your heart health. Consult your healthcare provider to find the best path forward!
What You Might Be Thinking?
1. Can I switch from Entresto to Losartan?
You may switch from Entresto to losartan, however, you must consult your doctor, as they work differently. Losartan is an ARB, while Entresto contains both an ARB and a neprilysin inhibitor.
2. What is the best over-the-counter alternative to Entresto?
There’s no direct OTC replacement, but supplements like CoQ10 and omega-3s can support heart health.
3. Is there a cheaper alternative to Entresto?
Generic ACE inhibitors and ARBs like Lisinopril and Losartan are more affordable.
4. Can I stop taking Entresto suddenly?
Stopping Entresto suddenly can worsen heart failure. Always consult your doctor before making changes.
5. How do I know if an alternative is right for me?
Talk to your doctor, and consider the cost, side effects, and effectiveness before switching medications.